compound 68 [PMID: 24900699]

Ligand id: 8165

Name: compound 68 [PMID: 24900699]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 112.02
Molecular weight 430.99
XLogP 4.17
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
The DYRK1A gene is located within the Down Syndrome (DS) critical region on chromosome 21. Trisomy of chromosome 21 leads to overexpression of DYRK1A and amyloid precursor protein (APP), and this may underlie the Tau and amyloid pathologies associated with early onset Alzheimer's disease in DS [1-3,5]. Pharmacological inhibition of DYRK1A activity would aim to modify the course of AD pathogenesis.