compound 68 [PMID: 24900699]

Ligand id: 8165

Name: compound 68 [PMID: 24900699]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 112.02
Molecular weight 430.99
XLogP 4.17
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Ferrer I, Barrachina M, Puig B, Martínez de Lagrán M, Martí E, Avila J, Dierssen M. (2005)
Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models.
Neurobiol. Dis.20 (2): 392-400. [PMID:16242644]
2. Kimura R, Kamino K, Yamamoto M, Nuripa A, Kida T, Kazui H, Hashimoto R, Tanaka T, Kudo T, Yamagata H et al.. (2007)
The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease.
Hum. Mol. Genet.16 (1): 15-23. [PMID:17135279]
3. Park J, Song WJ, Chung KC. (2009)
Function and regulation of Dyrk1A: towards understanding Down syndrome.
Cell. Mol. Life Sci.66 (20): 3235-40. [PMID:19685005]
4. Rosse G. (2013)
Tricyclic Pyrimidines As Inhibitors of DYRK1A/DYRK1B As Potential Treatment for Down's Syndrome or Alzheimer's Disease.
ACS Med Chem Lett4 (6): 502-3. [PMID:24900699]
5. Ryoo SR, Jeong HK, Radnaabazar C, Yoo JJ, Cho HJ, Lee HW, Kim IS, Cheon YH, Ahn YS, Chung SH et al.. (2007)
DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease.
J. Biol. Chem.282 (48): 34850-7. [PMID:17906291]