Ligand id: 8286

Name: tramadol

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 32.7
Molecular weight 263.19
XLogP 2.88
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Tramadol is indicated for the symptomatic treatment of moderate to severe pain.
Mechanism Of Action and Pharmacodynamic Effects
Tramadol acts via non-selective agonism of opioid receptors [1] to activate the spinal pain inhibitory system, with additional effects on the neurotransmission of noradrenalin and serotonin (descending inhibitory system, non-opioid effect) [2-3].
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