tramadol

Ligand id: 8286

Name: tramadol

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 32.7
Molecular weight 263.19
XLogP 2.88
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
δ receptor Agonist Agonist 8.0 pKi - 5
pKi 8.0 (Ki 9.4x10-9 M) [5]
Description: Displacement of the delta antagonist naltrindole from the delta receptor expressed in CHO cells.
κ receptor Agonist Agonist 7.8 pKi - 4
pKi 7.8 (Ki 1.4x10-8 M) [4]
Description: Displacement of the kappa agonist U69593 from the kappa receptor expressed in CHO cells.
μ receptor Agonist Agonist 5.8 pKi - 4
pKi 5.8 (Ki 1.6x10-6 M) [4]
Description: Displacement of the mu aginist peptide DAMGO from the mu receptor expressed in CHO cells.