Ligand id: 8311

Name: fadrozole

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 41.61
Molecular weight 223.11
XLogP 2.73
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Fadrozole is approved in Japan for the treatment of breast cancer [3].
Mechanism Of Action and Pharmacodynamic Effects
Fadrozole's action of inhibiting CYP19A1, reduces estrogen levels and is clinically effective in ER+ breast cancers [3].