Ligand id: 8311

Name: fadrozole

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 41.61
Molecular weight 223.11
XLogP 2.73
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Browne LJ, Gude C, Rodriguez H, Steele RE, Bhatnager A. (1991)
Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease.
J. Med. Chem.34 (2): 725-36. [PMID:1825337]
2. LaSala D, Shibanaka Y, Jeng AY. (2009)
Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors.
Anal. Biochem.394 (1): 56-61. [PMID:19622340]
3. Raats JI, Falkson G, Falkson HC. (1992)
A study of fadrozole, a new aromatase inhibitor, in postmenopausal women with advanced metastatic breast cancer.
J. Clin. Oncol.10 (1): 111-6. [PMID:1530798]