Ligand id: 8311

Name: fadrozole

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 41.61
Molecular weight 223.11
XLogP 2.73
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Browne LJ, Gude C, Rodriguez H, Steele RE, Bhatnager A. (1991)
Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease.
J. Med. Chem., 34 (2): 725-36. [PMID:1825337]
2. LaSala D, Shibanaka Y, Jeng AY. (2009)
Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors.
Anal. Biochem., 394 (1): 56-61. [PMID:19622340]
3. Raats JI, Falkson G, Falkson HC. (1992)
A study of fadrozole, a new aromatase inhibitor, in postmenopausal women with advanced metastatic breast cancer.
J. Clin. Oncol., 10 (1): 111-6. [PMID:1530798]