bempedoic acid

Ligand id: 8321

Name: bempedoic acid

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 14
Topological polar surface area 94.83
Molecular weight 344.26
XLogP 4.03
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Bempedoic acid is being investigated in Phase II clinical trials as a potential treatment for hyperlipidaemia and hypertsnsion..
Mechanism Of Action and Pharmacodynamic Effects
The anti-atherosclerotic, anti-obesity, and glucose-lowering properties exhibited by bempedoic acid are believed to be due to dual inhibition of sterol and fatty acid synthesis and enhanced mitochondrial long-chain fatty acid β-oxidation, although the underlying mechanisms are still to be elucidated. The compound is reported to activate AMP-activated protein kinase (AMPK) and inhibit ATP-citrate lyase (ACLY; P53396). AMPK detects and reacts to changes in the AMP:ATP ratio, regulating glucose uptake, β-oxidation of fatty acids and glucose transporter 4 (GLUT4) and mitochondria levels to maintain energy homeostasis. ACLY catalyses an important step in fatty acid biosynthesis [1] generating acetyl-CoA. ACLY links the metabolism of carbohydrates and the production of fatty acids,