anacetrapib

Ligand id: 8400

Name: anacetrapib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 9
Topological polar surface area 38.77
Molecular weight 637.17
XLogP 11.08
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Anacetrapib is being evaluated in Phase III clinical trials as a treatment for hypercholesterolemia and associated cardiovascular disease, including assessment in patients with heterozygous familial hypercholesterolemia [1].
Mechanism Of Action and Pharmacodynamic Effects
CETP facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins Inhibition of this enzyme reduces LDL-cholesterol levels [2-3].