Synonyms: AZD 2461 | AZD-2461
Compound class:
Synthetic organic
Comment: AZD2461 is an inhibitor of poly(ADP-ribose)polymerase (PARP) enzymes. AZD2461 is compound 2b in patent WO2009093032 A1 [3].
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No information available. |
Summary of Clinical Use |
AZD2461 has reached Phase 1 clinical trial in patients with refractory solid tumors (NCT01247168). |
Mechanism Of Action and Pharmacodynamic Effects |
PARP inhibitors are being investigated clinically as some cancers become dependent on PARP when other DNA repair mechanisms are defective (eg in BRCA mutated breast cancer cells). In suceptible tumour cells, inhibiting PARP activity causes the accumulation of double strand DNA breaks and this leads to cell death. PARP inhibitors may also be effective in other conditions [1] and may be effective against tumours harbouring mutations in the tumor suppressor protein PTEN. |