Ligand id: 8472

Name: AZD2461

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 58.64
Molecular weight 395.16
XLogP 4.1
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
AZD2461 has reached Phase I clinical trial in patients with refractory solid tumors (NCT01247168).
Mechanism Of Action and Pharmacodynamic Effects
PARP inhibitors are being investigated clinically as some cancers become dependent on PARP when other DNA repair mechanisms are defective (eg in BRCA mutated breast cancer cells). In suceptible tumour cells, inhibiting PARP activity causes the accumulation of double strand DNA breaks and this leads to cell death. PARP inhibitors may also be effective in other conditions [1] and may be effective against tumours harbouring mutations in the tumor suppressor protein PTEN.