Synonyms: AZD 2461 | AZD-2461
Compound class:
Synthetic organic
Comment: AZD2461 is an inhibitor of poly(ADP-ribose)polymerase (PARP) enzymes. AZD2461 is compound 2b in patent WO2009093032 A1 [3].
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References |
1. Graziani G, Szabó C. (2005)
Clinical perspectives of PARP inhibitors. Pharmacol Res, 52 (1): 109-18. [PMID:15911339] |
2. Jaspers JE, Kersbergen A, Boon U, Sol W, van Deemter L, Zander SA, Drost R, Wientjens E, Ji J, Aly A et al.. (2013)
Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors. Cancer Discov, 3 (1): 68-81. [PMID:23103855] |
3. Menear KA, Javaid MH, Gomez S, Hummersone MG, Lence CF, Martin NMB, Rudge DA, Roberts CA, Blades K. (2009)
Phthalazinone derivatives. Patent number: WO2009093032 A1. Assignee: Astrazeneca Ab.. Priority date: 23/01/2008. Publication date: 30/07/2009. |