Ligand id: 871

Name: rebamipide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 95.5
Molecular weight 370.07
XLogP 3.41
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used for mucosal protection, healing of gastroduodenal ulcers, and treatment of gastritis. There is no information regarding approval for clinical use of this drug on the US FDA or European Medicines Agency websites. Individual national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
This drug appears to enhance prostaglandin synthesis via the activation of COX-2 [2,4,6]. The gastroprotective action of the drug is further enhanced by increasing mucous production [3] and free-radical removal [7].