rebamipide

Ligand id: 871

Name: rebamipide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 95.5
Molecular weight 370.07
XLogP 3.41
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Arakawa T, Kobayashi K, Yoshikawa T, Tarnawski A. (1998)
Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing.
Dig. Dis. Sci.43 (9 Suppl): 5S-13S. [PMID:9753220]
2. Arakawa T, Watanabe T, Fukuda T, Yamasaki K, Kobayashi K. (1995)
Rebamipide, novel prostaglandin-inducer accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer. Comparison with cimetidine.
Dig. Dis. Sci.40 (11): 2469-72. [PMID:7587834]
3. Ishihara K, Komuro Y, Nishiyama N, Yamasaki K, Hotta K. (1992)
Effect of rebamipide on mucus secretion by endogenous prostaglandin-independent mechanism in rat gastric mucosa.
Arzneimittelforschung42 (12): 1462-6. [PMID:1337697]
4. Kleine A, Kluge S, Peskar BM. (1993)
Stimulation of prostaglandin biosynthesis mediates gastroprotective effect of rebamipide in rats.
Dig. Dis. Sci.38 (8): 1441-9. [PMID:8393757]
5. Moon SJ, An JM, Kim J, Lee SI, Ahn W, Kim KH, Seo JT. (2004)
Pharmacological characterization of rebamipide: its cholecystokinin CCK1 receptor binding profile and effects on Ca2+ mobilization and amylase release in rat pancreatic acinar cells.
Eur J Pharmacol505: 61-66. [PMID:15556137]
6. Tarnawski AS, Chai J, Pai R, Chiou SK. (2004)
Rebamipide activates genes encoding angiogenic growth factors and Cox2 and stimulates angiogenesis: a key to its ulcer healing action?.
Dig. Dis. Sci.49 (2): 202-9. [PMID:15104358]
7. Yoshikawa T, Naito Y, Tanigawa T, Kondo M. (1993)
Free radical scavenging activity of the novel anti-ulcer agent rebamipide studied by electron spin resonance.
Arzneimittelforschung43 (3): 363-6. [PMID:8387788]