Ligand id: 8746

Name: ajmalicine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 54.56
Molecular weight 352.18
XLogP 3.07
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
This appears to be approved for use as an antihypertensive agent.
Mechanism Of Action and Pharmacodynamic Effects
Hypotensive action is due to preferential antagonism of α1-adrenoceptor over α2-adrenoceptors [1]. Also potently inhibits cytochrome P450 2D6 (CYP2D6) [2].