tolfenamic acid

Ligand id: 8769

Name: tolfenamic acid

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: tolfenamic acid

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 49.33
Molecular weight 261.06
XLogP 4.57
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Approved in the UK to treat acute migraine. Not approved for use in the US, but is approved by individual national approval agencies (in some for veterinary use only).
Mechanism Of Action and Pharmacodynamic Effects
Like other NSAIDs tolfenamic acid is a COX inhibitor and prevents formation of prostaglandins.