tolfenamic acid

Ligand id: 8769

Name: tolfenamic acid

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View more information in the IUPHAR Pharmacology Education Project: tolfenamic acid

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 49.33
Molecular weight 261.06
XLogP 4.57
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Pentik√§inen PJ, Neuvonen PJ, Backman C. (1981)
Human pharmacokinetics of tolfenamic acid, a new anti-inflammatory agent.
Eur. J. Clin. Pharmacol.19 (5): 359-65. [PMID:7238564]
2. Qiu W, Zhou M, Mazumdar M, Azzi A, Ghanmi D, Luu-The V, Labrie F, Lin SX. (2007)
Structure-based inhibitor design for an enzyme that binds different steroids: a potent inhibitor for human type 5 17beta-hydroxysteroid dehydrogenase.
J. Biol. Chem.282 (11): 8368-79. [PMID:17166832]