ritonavir

Ligand id: 8804

Name: ritonavir

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 11
Hydrogen bond donors 4
Rotatable bonds 22
Topological polar surface area 202.26
Molecular weight 720.31
XLogP 8.59
No. Lipinski's rules broken 3

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat HIV+ve patients.
Mechanism Of Action and Pharmacodynamic Effects
Ritonavir prevents replication of human immunodeficiency virus (HIV) by inhibiting HIV protease. In addition, ritonavir inhibits metabolism of other antiretroviral protease inhibitors by hepatic cytochrome P450-3A4 (CYP3A4), thereby increasing their duration of action [3].