Ligand id: 8993

Name: neostigmine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 29.54
Molecular weight 223.14
XLogP 1.76
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat myasthenia gravis, to reverse the effects of muscle relaxants such as gallamine and tubocurarine, and may be used in the management of paralytic ileus, post-operative urinary retention and paroxysmal supraventricular tachycardia.
Mechanism Of Action and Pharmacodynamic Effects
Inhibits acetylcholinesterase, thereby increasing the level and duration of action of the neurotransmitter acetylcholine.
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