pimozide

Ligand id: 90

Name: pimozide

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: pimozide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 35.58
Molecular weight 461.23
XLogP 7.81
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat schizophrenia, and may be effective for the suppression of motor and phonic tics in patients with Tourette's Disorder who have failed to respond to standard treatments.
Mechanism Of Action and Pharmacodynamic Effects
Inhibition of dopamine D2 receptors in the CNS is thought to be responsible for the suppression of tics in Tourette's Disorder.
External links