Ligand id: 9025

Name: 852A

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 111.28
Molecular weight 361.16
XLogP 2.45
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
852A has completed Phase II clinical trials in patients with metastatic melanoma (NCT00189332) and breast, ovarian, endometrial and cervical cancers (NCT00319748). An additional Phase II trial in hematologic malignancies (NCT00276159) was terminated.