acumapimod

Ligand id: 9203

Name: acumapimod

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 113.8
Molecular weight 385.15
XLogP 3.28
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Acumapimod is being evaluated in Phase 2 clinical trial (NCT02700919) for the treatment of acute exacerbations of chronic obstructive pulmonary disease (AECOPD).
Mechanism Of Action and Pharmacodynamic Effects
The p38 mitogen-activated protein kinase is a key signaling pathway involved in regulation of inflammatory cytokines.