Ligand id: 93

Name: pizotifen

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 31.48
Molecular weight 295.14
XLogP 5.17
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Pizotifen is not approved by the US FDA or EMA. In the UK, pizotifen hydrogen malate (PubChem CID 168993) is sold as generic tablets, or as Sanomigran® tablets for the prophylactic treatment of migraine and cluster headaches.
Mechanism Of Action and Pharmacodynamic Effects
Pizotifen acts predominantly as a serotonin antagonist, acting mainly at the 5-HT2A and 5HT2C receptors, with minor antihistamine and anticholinergic activity