Ligand id: 9395

Name: tofogliflozin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 4
Topological polar surface area 99.38
Molecular weight 386.17
XLogP 5.25
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Approved in Japan for the treatment of type 2 diabetes [3]. This approval permits tofogliflozin to be prescribed either as monotherapy or in combination with other antihyperglcaemic agents. Post-approval monitoring as an add-on treatment to insulin is being provided by Phase 4 clinical trial NCT02201004.