Ligand id: 9395

Name: tofogliflozin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 4
Topological polar surface area 99.38
Molecular weight 386.17
XLogP 5.25
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

1. Faillie JL. (2017)
Pharmacological aspects of the safety of gliflozins.
Pharmacol. Res., 118: 71-81. [PMID:27389050]
2. Ohtake Y, Sato T, Kobayashi T, Nishimoto M, Taka N, Takano K, Yamamoto K, Ohmori M, Yamaguchi M, Takami K et al.. (2012)
Discovery of tofogliflozin, a novel C-arylglucoside with an O-spiroketal ring system, as a highly selective sodium glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.
J. Med. Chem., 55 (17): 7828-40. [PMID:22889351]
3. Poole RM, Prossler JE. (2014)
Tofogliflozin: first global approval.
Drugs, 74 (8): 939-44. [PMID:24848755]