Ligand id: 9412

Name: AZD7986

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 103.69
Molecular weight 420.18
XLogP 3.83
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
AZD7986 has completed Phase 1 clinical trials in healthy volunteers (see NCT02303574 and NCT02653872).
Mechanism Of Action and Pharmacodynamic Effects
Cathepsin C cleaves the N-terminal dipeptide of neutrophil serine proteases (NSPs) during neutrophil maturation in the bone marrow. This action leads to neutrophils without stored activated NSPs (e.g. neutrophil elastase, proteinase 3, and cathepsin G). In neutrophil-driven lung disease, treatment with cathepsin C inhibitors should reduce availability of the active NSPs that cause inflammatory lung damage, leading to improvement of disease symptoms.