empesertib

Ligand id: 9427

Name: empesertib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 123.07
Molecular weight 559.17
XLogP 5.12
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
BAY1161909 in combination with paclitaxel is being evaluated in a Phase 1 dose escalation clinical study in patients with a variety of advanced malignancies (see NCT02138812).
Mechanism Of Action and Pharmacodynamic Effects
Inhibition of Mps1 induces death of cancer cells overexpressing Mps1 by inactivating the spindle assembly checkpoint (SAC) and promoting mitosis, chromosomal misalignment, chromosomal missegregation, mitotic checkpoint complex destabilization, and increasing aneuploidy.