Ligand id: 948

Name: flupentixol

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View more information in the IUPHAR Pharmacology Education Project: flupentixol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 52.01
Molecular weight 434.16
XLogP 4.91
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Flupentixol may be used in the treatment of schizophrenia and depression. However, there is no information regarding approval for use of this compound on the US FDA website, although the compound does have an INN. Other national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
Antagonist of dopamine D1 and D2 receptors thereby increasing the levels of central serotonin and noradrenaline and in turn improving mood.