Ligand id: 96

Name: risperidone

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View more information in the IUPHAR Pharmacology Education Project: risperidone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 49.58
Molecular weight 410.21
XLogP 4.01
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Antipsychotic used in the treatment of schizophrenia, manic episodes of bipolar disorder and irritability in autism.
Mechanism Of Action and Pharmacodynamic Effects
Risperidone displays affinity for a range of receptors across the 5-HT, dopamine, histamine, and adrenoceptor families. Its properties as an antipsychotic are believed to arise from its antagonism of dopamine D2 and 5-HT2A receptors.
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