Ligand id: 98

Name: sertindole

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 40.51
Molecular weight 440.18
XLogP 4.22
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Atypical antipsychotic used in the treatment of schizophrenia. Although this drug was withdrawn in some countries due to concerns over cardiovascular adverse effects, some national regulatory authorities maintain approval, such as in Australia where sertindole is indicated only for treatment of patients whose schizophrenia is not responsive to, or who are intolerant of other antipsychotic medicines. This drug is not approved in the US. In October 2001, the EMA lifted a marketing suspension, but imposed restrictions on the approval (click here to view the EMA's summary/review of sertindole's marketing authorisation).
Mechanism Of Action and Pharmacodynamic Effects
Antagonist at a range of GPCRs, namely dopamine D2 receptors, serotonin 5-HT2A and 5-HT2C receptors and α1-adrenoceptors.