galectin-1

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Ligands
galectin-1 (Human)

GtoPdb Ligand ID: 6603

Synonyms: GBP

Compound class: Endogenous peptide in human, mouse or rat

Comment: Gal-1 is a mammalian lectin that is active in the immune system. Its participation in the induction of self-tolerance suggests that any altered activity could lead to a failure to select out autoreactive cells, which may be relevant to autoimmune disease pathogenesis.

Species: Human

Summary
Biological activity
References
Structure
Immunopharmacology

Immunopharmacology Comments
Gal-1 is a mammalian lectin that modulates T cell function and apoptosis. Gal-1 (expressed by stromal cells) is also required for the development of B cells in the bone marrow [3] and contributes to the induction of B cells regulatory function [1].

Immunopharmacology Comments

Gal-1 is a mammalian lectin that modulates T cell function and apoptosis. Gal-1 (expressed by stromal cells) is also required for the development of B cells in the bone marrow [3] and contributes to the induction of B cells regulatory function [1].

Immunopharmacology Disease
Disease	X-Refs	Comment	References
Graft versus host disease		Gal-1 reduces host alloreactivity and suppresses the graft versus host immune response in animal GvHD models, leading to increased survival.	2