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Synonyms: GBP
Compound class:
Endogenous peptide in human, mouse or rat
Comment: Gal-1 is a mammalian lectin that is active in the immune system. Its participation in the induction of self-tolerance suggests that any altered activity could lead to a failure to select out autoreactive cells, which may be relevant to autoimmune disease pathogenesis.
Species: Human
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| References |
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1. Alhabbab R, Blair P, Smyth LA, Ratnasothy K, Peng Q, Moreau A, Lechler R, Elgueta R, Lombardi G. (2018)
Galectin-1 is required for the regulatory function of B cells. Sci Rep, 8 (1): 2725. [PMID:29426942] |
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2. Baum LG, Blackall DP, Arias-Magallano S, Nanigian D, Uh SY, Browne JM, Hoffmann D, Emmanouilides CE, Territo MC, Baldwin GC. (2003)
Amelioration of graft versus host disease by galectin-1. Clin Immunol, 109 (3): 295-307. [PMID:14697744] |
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3. Espeli M, Mancini SJ, Breton C, Poirier F, Schiff C. (2009)
Impaired B-cell development at the pre-BII-cell stage in galectin-1-deficient mice due to inefficient pre-BII/stromal cell interactions. Blood, 113 (23): 5878-86. [PMID:19329777] |
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4. Walzel H, Schulz U, Neels P, Brock J. (1999)
Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45. Immunol Lett, 67 (3): 193-202. [PMID:10369126] |
