gevokizumab   Click here for help

GtoPdb Ligand ID: 7394

Synonyms: XOMA 052 | XOMA-052
Immunopharmacology Ligand
Compound class: Antibody
Comment: Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
Immunopharmacology Comments
Gevokizumab down-modulates, rather than completely blocks, IL-1β signalling capacity. It has therapeutic potential to treat inflammatory conditions where IL1β is a contributory factor, including type 2 diabetes mellitus, rheumatoid arthritis and cardiovascular disease [2,5-6].
Immunopharmacology Disease
Disease X-Refs Comment References
Uveitis Disease Ontology: DOID:13141
Approved therapeutic for uveitis.
Uveitis Disease Ontology: DOID:13141
Gevokizumab is a FDA and EMA orphan drug for the management of chronic non-infectious uveitis. 1,7