diamorphine

Ligand id: 9082

Name: diamorphine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 65.07
Molecular weight 369.16
XLogP 2.28
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Immunopharmacology Comments
Evidence gained from studying the immune responses of heroin addicts undergoing methadone maintenance treatment, suggest that methadone maintenance treatment/opioid-dependency may induce long-term systemic inflammation [1]. In this study patients receiving methadone therapy had significantly increased levels of IL-1β, IL-6 , IL-8 and TNF-α compared to controls. Another study indicates that heroin injecting drug users have a dysregulated humoral profile (compared to controls) which is suggestive of elevated systemic inflammation [3].