CORM-2

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Ligands
CORM-2

GtoPdb Ligand ID: 9535

Comment: CORM-2 is a ruthenium-containing carbon monoxide (CO)-releasing pro-drug. CORM is an acronym for CO-releasing molecule. The therapeutic potential (antioxidant, anti-inflammatory, and anti-tumor properties) of such drugs is reviewed in [3].

CORM-2 is commercially available from our sponsors

Summary
Biological activity
References
Immunopharmacology

Immunopharmacology Comments
CORM-2 inhibits the TXNIP/NLRP3 inflammasome pathway in LPS-induced acute lung injury [1], and reduces IL-1β-induced IL-8 expression and endothelial cell proliferation in the tumor microenvironment in vitro [2].

Immunopharmacology Comments

CORM-2 inhibits the TXNIP/NLRP3 inflammasome pathway in LPS-induced acute lung injury [1], and reduces IL-1β-induced IL-8 expression and endothelial cell proliferation in the tumor microenvironment in vitro [2].