example 36 [WO2016177845]

Ligand id: 9555

Name: example 36 [WO2016177845]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 79.73
Molecular weight 442.19
XLogP 4.96
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Immunopharmacology Comments
For asthma, reduction of cys-LTs production (which are potent bronchoconstrictors and proinflammatory mediators) by blocking LTC4S would be an approach that circumvents multiple receptors to reduce airway inflammation [1].
Immunopharmacology Disease
Disease X-Refs Comment References
Asthma Disease Ontology: DOID:2841
OMIM: 600807
A novel LTC4S inhibitor with potential anti-inflammatory effects in respiratory conditions such as asthma. 1