|
Synonyms: E6071 | KANAb071
Compound class:
Antibody
Comment: GSK3050002 is a humanized IgG1κ antibody with high binding affinity to the human chemokine, CCL20. This biologic is being developed by GlaxoSmithKline in collaboration with Morphotek, based on a non-humanized antibody originally identified by KAN Research Institute, Inc., a subsidiary of Eisai Co., Ltd.
|
| Immunopharmacology Comments |
| Intravenously administered GSK3050002 effectively neutralizes circulating CCL20 to down-modulate the CCL20/CCR6 interaction and recruitment of CCR6+ cells to inflammatory sites [1]. The CCL20/CCR6 interaction is implicated in a range of autoimmune diseases. |
| Immunopharmacology Disease | |||
| Disease | X-Refs | Comment | References |
| Psoriatic arthritis |
Disease Ontology:
DOID:9008 |
Phase 1 clinical candidate for PsA. | |
