vermisporin   Click here for help

GtoPdb Ligand ID: 11011

Compound class: Natural product or derivative
Comment: Vermisporin is an antibacterial produced by the fungus Ophiobolus vermisporis [1]. It has Gram-negative and Gram-positive activity, and has antitubercular activity [2].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 70.14
Molecular weight 415.27
XLogP 5.74
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES C[C@H]1C[C@@H](C)[C@@H]2[C@H](C1)C=CC([C@H]2/C(=C/1\C(=O)[C@@H](N(C1=O)C)C(C)C)/O)[C@]1(C)O[C@H]1C
Isomeric SMILES C[C@H]1C[C@@H](C)[C@@H]2[C@H](C1)C=CC([C@H]2/C(=C/1\C(=O)[C@@H](N(C1=O)C)C(C)C)/O)[C@]1(C)O[C@H]1C
InChI InChI=1S/C25H37NO4/c1-12(2)21-23(28)20(24(29)26(21)7)22(27)19-17(25(6)15(5)30-25)9-8-16-11-13(3)10-14(4)18(16)19/h8-9,12-19,21,27H,10-11H2,1-7H3/b22-20-/t13-,14+,15-,16-,17?,18+,19+,21-,25+/m0/s1
InChI Key OBDFYDGODWWFEX-UDEGNFRISA-N
References
1. Chin NX, Neu HC. (1992)
In vitro antimicrobial activity of the new antibiotic vermisporin.
Eur J Clin Microbiol Infect Dis, 11 (8): 755-7. [PMID:1425739]
2. Ganihigama DU, Sureram S, Sangher S, Hongmanee P, Aree T, Mahidol C, Ruchirawat S, Kittakoop P. (2015)
Antimycobacterial activity of natural products and synthetic agents: pyrrolodiquinolines and vermelhotin as anti-tubercular leads against clinical multidrug resistant isolates of Mycobacterium tuberculosis.
Eur J Med Chem, 89: 1-12. [PMID:25462220]
3. Hwang C, Jaki B, Napolitano J, Lankin D, McAlpine J, Franzblau S, Cho S, Pearce C, Pauli G. (2012)
Biological and chemical assessment of vermisporin, an anti-TB active metabolite from the fungus MSX 105528.
Planta Med, 78: PI90.