Ligand id: 1229

Name: burimamide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 7
Topological polar surface area 84.83
Molecular weight 262.13
XLogP 3.14
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Alewijnse AE, Smit MJ, Hoffmann M, Verzijl D, Timmerman H, Leurs R. (1998)
Constitutive activity and structural instability of the wild-type human H2 receptor.
J Neurochem, 71: 799-807. [PMID:9681472]
2. Lim HD, van Rijn RM, Ling P, Bakker RA, Thurmond RL, Leurs R. (2005)
Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist.
J Pharmacol Exp Ther, 314: 1310-1321. [PMID:15947036]
3. Liu C, Ma X, Jiang X, Wilson SJ, Hofstra CL, Blevitt J, Pyati J, Li X, Chai W, Carruthers N, Lovenberg TW. (2001)
Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow.
Mol Pharmacol, 59: 420-426. [PMID:11179434]
4. Liu C, Wilson SJ, Kuei C, Lovenberg TW. (2001)
Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation.
J Pharmacol Exp Ther, 299: 121-130. [PMID:11561071]
5. Morse KL, Behan J, Laz TM, West RE, Greenfeder SA, Anthes JC, Umland S, Wan Y, Hipkin RW, Gonsiorek W, Shin N, Gustafson EL, Qiao X, Wang S, Hedrick JA, Greene J, Bayne M, Monsma FJ. (2001)
Cloning and characterization of a novel human histamine receptor.
J Pharmacol Exp Ther, 296: 1058-1066. [PMID:11181941]
6. Smit MJ, Leurs R, Alewijnse AE, Blauw J, Van Nieuw Amerongen GP, Van De Vrede Y, Roovers E, Timmerman H. (1996)
Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors.
Proc Natl Acad Sci U S A, 93: 6802-6807. [PMID:8692899]
7. Wieland K, Bongers G, Yamamoto Y, Hashimoto T, Yamatodani A, Menge WM, Timmerman H, Lovenberg TW, Leurs R. (2001)
Constitutive activity of histamine h(3) receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H(3) antagonists.
J Pharmacol Exp Ther, 299: 908-914. [PMID:11714875]
8. Zhu Y, Michalovich D, Wu H, Tan KB, Dytko GM, Mannan IJ, Boyce R, Alston J, Tierney LA, Li X, Herrity NC, Vawter L, Sarau HM, Ames RS, Davenport CM, Hieble JP, Wilson S, Bergsma DJ, Fitzgerald LR. (2001)
Cloning, expression, and pharmacological characterization of a novel human histamine receptor.
Mol Pharmacol, 59: 434-441. [PMID:11179436]