nifuroxazide   Click here for help

GtoPdb Ligand ID: 12358

Synonyms: NSC-759261 | RC-27109 | SJ000287313
Approved drug
nifuroxazide is an approved drug
Compound class: Synthetic organic
Comment: Nifuroxazide is a nitrofuran drug with broad-spectrum antibacterial activity. In addition to its antibacterial activity, nifuroxazide has been found to be a potent inhibitor of STAT3 and aldehyde dehydrogenase, and may have the potential to be repurposed as an antineoplastic therapy [1].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 117.97
Molecular weight 275.05
XLogP 2.35
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES Oc1ccc(cc1)C(=O)N/N=C/c1ccc(o1)[N+](=O)[O-]
Isomeric SMILES c1cc(ccc1C(=O)N/N=C/c1ccc(o1)[N+](=O)[O-])O
InChI InChI=1S/C12H9N3O5/c16-9-3-1-8(2-4-9)12(17)14-13-7-10-5-6-11(20-10)15(18)19/h1-7,16H,(H,14,17)/b13-7+
InChI Key YCWSUKQGVSGXJO-NTUHNPAUSA-N
References
1. Bailly C. (2019)
Toward a repositioning of the antibacterial drug nifuroxazide for cancer treatment.
Drug Discov Today, 24 (9): 1930-1936. [PMID:31260646]
2. Cevik UA, Saglik BN, Ozkay Y, Canturk Z, Bueno J, Demirci F, Koparal AS. (2017)
Synthesis of New Fluoro-Benzimidazole Derivatives as an Approach towards the Discovery of Novel Intestinal Antiseptic Drug Candidates.
Curr Pharm Des, 23 (15): 2276-2286. [PMID:27908268]