fleroxacin   Click here for help

GtoPdb Ligand ID: 12476

Synonyms: AM-833 | Megalone® | Quinodis® | Ro 23-6240
Approved drug
fleroxacin is an approved drug
Compound class: Synthetic organic
Comment: Fleroxacin is a fluoroquinolone compound with a broad-spectrum of antibacterial activity [2].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 64.09
Molecular weight 369.34
XLogP 2.25
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CN1CCN(CC1)C2=C(C3=C(C=C2F)C(=O)C(=CN3CCF)C(=O)O)F
Isomeric SMILES CN1CCN(CC1)C2=C(C=C3C(=C2F)N(C=C(C3=O)C(=O)O)CCF)F
InChI InChI=1S/C17H18F3N3O3/c1-21-4-6-22(7-5-21)15-12(19)8-10-14(13(15)20)23(3-2-18)9-11(16(10)24)17(25)26/h8-9H,2-7H2,1H3,(H,25,26)
InChI Key XBJBPGROQZJDOJ-UHFFFAOYSA-N
References
1. Balfour JA, Todd PA, Peters DH. (1995)
Fleroxacin. A review of its pharmacology and therapeutic efficacy in various infections.
Drugs, 49 (5): 794-850. [PMID:7601015]
2. Hirai K, Aoyama H, Hosaka M, Oomori Y, Niwata Y, Suzue S, Irikura T. (1986)
In vitro and in vivo antibacterial activity of AM-833, a new quinolone derivative.
Antimicrob Agents Chemother, 29 (6): 1059-66. [PMID:2942103]
3. Rusu A, Lungu IA, Moldovan OL, Tanase C, Hancu G. (2021)
Structural Characterization of the Millennial Antibacterial (Fluoro)Quinolones-Shaping the Fifth Generation.
Pharmaceutics, 13 (8). [PMID:34452252]