prontosil   Click here for help

GtoPdb Ligand ID: 12743

Synonyms: prontosil red | prontosil rubrum | sulfamidochrysoidine
Compound class: Synthetic organic
Comment: Prontosil is a sulfonamide antibacterial compound and the first drug available commercially for the treatment of bacterial infections. It is a prodrug of sulfanilamide. The antibacterial properties of prontosil were first identified by Gerhard Domagk (Bayer Laboratories) in the early 1930s, leading to him being awarded the 1939 Nobel Prize in Physiology or Medicine [5].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 3
Topological polar surface area 145.3
Molecular weight 291.33
XLogP -0.19
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES C1=C(C=C(C(=C1)N=NC2=CC=C(C=C2)S(=O)(=O)N)N)N
Isomeric SMILES C1=CC(=CC=C1N=NC2=C(C=C(C=C2)N)N)S(=O)(=O)N
InChI InChI=1S/C12H13N5O2S/c13-8-1-6-12(11(14)7-8)17-16-9-2-4-10(5-3-9)20(15,18)19/h1-7H,13-14H2,(H2,15,18,19)
InChI Key ABBQGOCHXSPKHJ-UHFFFAOYSA-N
References
1. Achari A, Somers DO, Champness JN, Bryant PK, Rosemond J, Stammers DK. (1997)
Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase.
Nat Struct Biol, 4 (6): 490-7. [PMID:9187658]
2. Bermingham A, Derrick JP. (2002)
The folic acid biosynthesis pathway in bacteria: evaluation of potential for antibacterial drug discovery.
Bioessays, 24 (7): 637-48. [PMID:12111724]
3. Bickel MH. (1988)
The development of sulfonamides (1932-1938) as a focal point in the history of chemotherapy.
Gesnerus, 45 Pt 1: 67-86. [PMID:3042521]
4. Iyer HV. (2008)
History revisited-Prontosil red.
J Emerg Med, 35 (2): 209-10. [PMID:18280088]
5. Raju TN. (1999)
The Nobel chronicles. 1939: Gerhard Domagk (1895-1964).
Lancet, 353 (9153): 681. [PMID:10030374]