[Phe13,Tyr19]MCH   Click here for help

GtoPdb Ligand ID: 1297

Synonyms: [Phe13,Tyr19]-melanin-concentrating hormone
Compound class: Peptide or derivative
Comment: Synthetic analogue of MCH
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Chambers J, Ames RS, Bergsma D, Muir A, Fitzgerald LR, Hervieu G, Dytko GM, Foley JJ, Martin J, Liu WS et al.. (1999)
Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1.
Nature, 400 (6741): 261-5. [PMID:10421367]
2. Kokkotou EG, Tritos NA, Mastaitis JW, Slieker L, Maratos-Flier E. (2001)
Melanin-concentrating hormone receptor is a target of leptin action in the mouse brain.
Endocrinology, 142 (2): 680-6. [PMID:11159839]
3. Sailer AW, Sano H, Zeng Z, McDonald TP, Pan J, Pong SS, Feighner SD, Tan CP, Fukami T, Iwaasa H et al.. (2001)
Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R.
Proc Natl Acad Sci USA, 98 (13): 7564-9. [PMID:11404457]
4. Suply T, Della Zuana O, Audinot V, Rodriguez M, Beauverger P, Duhault J, Canet E, Galizzi JP, Nahon JL, Levens N et al.. (2001)
SLC-1 receptor mediates effect of melanin-concentrating hormone on feeding behavior in rat: a structure-activity study.
J Pharmacol Exp Ther, 299 (1): 137-46. [PMID:11561073]
5. Wang S, Behan J, O'Neill K, Weig B, Fried S, Laz T, Bayne M, Gustafson E, Hawes BE. (2001)
Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2.
J Biol Chem, 276 (37): 34664-70. [PMID:11459838]