Synonyms: AMG-714 | AMG714 | MAb146B7 | PRV-015
Compound class:
Antibody
Comment: Ordesekimab (AMG714, formerly PRV-015) is a fully human anti-IL-15 monoclonal antibody [1]. It binds to Il-15-IL-15Rα complexes on monocytes and disrupts interaction of the cytokine-bound receptor α subunit with the IL-2Rβ and common γ chains of the IL-15 receptor complex that is necessary for receptor activation and downstream signalling.
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References |
1. Wei YL, Wegesser T, Kuhns S, Werner J, Lebrec H, Wang X. (2022)
Strategies to evaluate potential effector function of glycan variants: a case study of ordesekimab (AMG 714 or PRV-015). J Immunotoxicol, 19 (1): 109-116. [PMID:36083248] |