catechin   Click here for help

GtoPdb Ligand ID: 13091

Synonyms: (+)-catechin | catechol | cianidanol | D-Catechin
PDB Ligand
Compound class: Natural product or derivative
Comment: Catechin is a plant-derived flavonoid (from Acacia catechu, and cacao, grapes and tea plants). This entry represents the 2R,3S diastereoisomer, but 3 others are possible given that the molecule has two chiral centers. Catechin has relatively low antioxidant properties compared to other flavonoids.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 5
Rotatable bonds 1
Topological polar surface area 110.38
Molecular weight 290.27
XLogP 0.58
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES C1=C(C=C(C(=C1)O)O)[C@@H]2[C@H](CC3=C(C=C(C=C3O)O)O2)O
Isomeric SMILES C1[C@@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O
InChI InChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15+/m0/s1
InChI Key PFTAWBLQPZVEMU-DZGCQCFKSA-N
References
1. American Society of Health-System Pharmacists (ASHP). 
Sinecatechins (Monograph).
Accessed on 16/01/2024. Modified on 16/01/2024. Drugs.com, https://www.drugs.com/monograph/sinecatechins.html
2. Jeong GH, Cho JH, Kim TH. (2019)
A new approach to procyanidins synthesis with potent anti-adipogenic effects.
Bioorg Med Chem Lett, 29 (16): 2079-2084. [PMID:31300342]