|
Synonyms: N-Aβ(10-15) | N-Aβ10-15 | N-Aβcore
Compound class:
Peptide or derivative
Comment: This hexapetide has been determined as the functional core sequence of N-terminal Aβ fragment amyloid β1-16. It constitutes residues 10-15 in the C-terminal region of the parent Aβ1-42 peptide. This 6-mer retains all of the neuromodulatory and neuro-protective actions of amyloid β1-16 against Aβ-induced neurotoxicity [1].
|
| References |
|
1. Forest KH, Taketa R, Arora K, Todorovic C, Nichols RA. (2021)
The Neuroprotective Beta Amyloid Hexapeptide Core Reverses Deficits in Synaptic Plasticity in the 5xFAD APP/PS1 Mouse Model. Front Mol Neurosci, 14: 576038. [PMID:33912008] |
