[3H]diprenorphine

Ligand id: 1612

Name: [3H]diprenorphine    

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 62.16
Molecular weight 425.26
XLogP 2.82
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Ann DK, Hasegawa J, Ko JL, Chen ST, Lee NM, Loh HH. (1992)
Specific reduction of delta-opioid receptor binding in transfected NG108-15 cells.
J. Biol. Chem.267 (11): 7921-6. [PMID:1313812]
2. Raynor K, Kong H, Chen Y, Yasuda K, Yu L, Bell GI, Reisine T. (1994)
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
Mol Pharmacol45: 330-334. [PMID:8114680]
3. Simonin F, Gaveriaux-Ruff C, Befort K, Matthes H, Lannes B, Micheletti G, Mattei MG, Charron G, Bloch B, Kieffer B. (1995)
kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system.
Proc Natl Acad Sci U S A92: 7006-7010. [PMID:7624359]
4. Toll L, Berzetei-Gurske IP, Polgar WE, Brandt SR, Adapa ID, Rodriguez L, Schwartz RW, Haggart D, O'Brien A, White A, Kennedy JM, Craymer K, Farrington L, Auh JS. (1998)
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.

NOTE: This paper is available through the website of the International Narcotics Research Conference, at http://www.inrcworld.org/links2.htm.
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NIDA Res Monogr178: 440-466. [PMID:9686407]