Ligand id: 1756

Name: AR-C67085

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 17
Hydrogen bond donors 7
Rotatable bonds 11
Topological polar surface area 324.63
Molecular weight 646.96
XLogP -3.35
No. Lipinski's rules broken 3

Molecular properties generated using the CDK

1. Balogh J, Wihlborg AK, Isackson H, Joshi BV, Jacobson KA, Arner A, Erlinge D. (2005)
Phospholipase C and cAMP-dependent positive inotropic effects of ATP in mouse cardiomyocytes via P2Y11-like receptors.
J Mol Cell Cardiol, 39: 223-230. [PMID:15893764]
2. Communi D, Robaye B, Boeynaems JM. (1999)
Pharmacological characterization of the human P2Y11 receptor.
Br. J. Pharmacol., 128: 1199-1206. [PMID:10578132]
3. Kennedy C, Chootip K, Mitchell C, Syed NI, Tengah A. (2013)
P2X and P2Y nucleotide receptors as targets in cardiovascular disease.
Future Med Chem, 5 (4): 431-49. [PMID:23495690]