BW 245C

Ligand id: 1878

Name: BW 245C

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 106.94
Molecular weight 368.23
XLogP 2.81
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

1. Boie Y, Sawyer N, Slipetz DM, Metters KM, Abramovitz M. (1995)
Molecular cloning and characterization of the human prostanoid DP receptor.
J. Biol. Chem., 270: 18910-18916. [PMID:7642548]
2. Kiriyama M, Ushikubi F, Kobayashi T, Hirata M, Sugimoto Y, Narumiya S. (1997)
Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells.
Br. J. Pharmacol., 122: 217-224. [PMID:9313928]
3. Wright DH, Metters KM, Abramovitz M, Ford-Hutchinson AW. (1998)
Characterization of the recombinant human prostaglandin DP-receptor identifies L-644,698 a novel, DP-selective agonist.
Br. J. Pharmacol., 123: 1317-1324. [PMID:9579725]
4. Wright DH, Nantel F, Metters KM, Ford-Hutchinson AW. (1999)
A novel biological role for prostaglandin D2 is suggested by distribution studies of the rat DP prostanoid receptor.
Eur J Pharmacol, 377: 101-115. [PMID:10448933]