Ligand id: 2314

Name: EBIO

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 32.34
Molecular weight 162.08
XLogP 1.78
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Cao Y, Dreixler JC, Roizen JD, Roberts MT, Houamed KM. (2001)
Modulation of recombinant small-conductance Ca(2+)-activated K(+) channels by the muscle relaxant chlorzoxazone and structurally related compounds.
J. Pharmacol. Exp. Ther., 296 (3): 683-9. [PMID:11181893]
2. Grunnet M, Jespersen T, Angelo K, Frøkjaer-Jensen C, Klaerke DA, Olesen SP, Jensen BS. (2001)
Pharmacological modulation of SK3 channels.
Neuropharmacology, 40 (7): 879-87. [PMID:11378158]
3. Pedarzani P, McCutcheon JE, Rogge G, Jensen BS, Christophersen P, Hougaard C, Strøbaek D, Stocker M. (2005)
Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons.
J. Biol. Chem., 280 (50): 41404-11. [PMID:16239218]
4. Pedarzani P, Mosbacher J, Rivard A, Cingolani LA, Oliver D, Stocker M, Adelman JP, Fakler B. (2001)
Control of electrical activity in central neurons by modulating the gating of small conductance Ca2+-activated K+ channels.
J. Biol. Chem., 276 (13): 9762-9. [PMID:11134030]
5. Syme CA, Gerlach AC, Singh AK, Devor DC. (2000)
Pharmacological activation of cloned intermediate- and small-conductance Ca(2+)-activated K(+) channels.
Am. J. Physiol., Cell Physiol., 278 (3): C570-81. [PMID:10712246]
6. Weatherall KL, Goodchild SJ, Jane DE, Marrion NV. (2010)
Small conductance calcium-activated potassium channels: from structure to function.
Prog. Neurobiol., 91 (3): 242-55. [PMID:20359520]
7. Wittekindt OH, Visan V, Tomita H, Imtiaz F, Gargus JJ, Lehmann-Horn F, Grissmer S, Morris-Rosendahl DJ. (2004)
An apamin- and scyllatoxin-insensitive isoform of the human SK3 channel.
Mol. Pharmacol., 65 (3): 788-801. [PMID:14978258]