Ligand id: 2334

Name: nitrendipine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 107.77
Molecular weight 360.13
XLogP 4.33
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Beam KG, Knudson CM. (1988)
Calcium currents in embryonic and neonatal mammalian skeletal muscle.
J. Gen. Physiol., 91 (6): 781-98. [PMID:2458429]
2. Bean BP. (1984)
Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state.
Proc. Natl. Acad. Sci. U.S.A., 81 (20): 6388-92. [PMID:6093100]
3. Jensen BS, Strobaek D, Christophersen P, Jorgensen TD, Hansen C, Silahtaroglu A, Olesen SP, Ahring PK. (1998)
Characterization of the cloned human intermediate-conductance Ca2+-activated K+ channel.
Am. J. Physiol., 275 (3 Pt 1): C848-56. [PMID:9730970]
4. Sinnegger-Brauns MJ, Huber IG, Koschak A, Wild C, Obermair GJ, Einzinger U, Hoda JC, Sartori SB, Striessnig J. (2009)
Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms.
Mol. Pharmacol., 75 (2): 407-14. [PMID:19029287]
5. Wulff H, Miller MJ, Hansel W, Grissmer S, Cahalan MD, Chandy KG. (2000)
Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant.
Proc. Natl. Acad. Sci. U.S.A., 97 (14): 8151-6. [PMID:10884437]
6. Xu W, Lipscombe D. (2001)
Neuronal Ca(V)1.3alpha(1) L-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridines.
J. Neurosci., 21 (16): 5944-51. [PMID:11487617]