ivabradine

Ligand id: 2357

Name: ivabradine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 10
Topological polar surface area 60.47
Molecular weight 468.26
XLogP 2.57
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Bucchi A, Tognati A, Milanesi R, Baruscotti M, DiFrancesco D. (2006)
Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels.
J. Physiol. (Lond.)572 (Pt 2): 335-46. [PMID:16484306]
2. DiFrancesco D, Camm JA. (2004)
Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease.
Drugs64 (16): 1757-65. [PMID:15301560]
3. Stieber J, Wieland K, Stöckl G, Ludwig A, Hofmann F. (2006)
Bradycardic and proarrhythmic properties of sinus node inhibitors.
Mol. Pharmacol.69 (4): 1328-37. [PMID:16387796]